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Article

The tumor necrosis factor polymorphism TNF (-308) is associated with susceptibility to meningococcal sepsis, but not with lethality.

Critical care medicine - 1 Apr 2009

Read Robert C, Teare Dawn M, Pridmore Alison C, Naylor Simone C, Timms James M, Kaczmarski Edward B, Borrow Raymond, Wilson Anthony G

Abstract excerpt

OBJECTIVE: To determine whether the promoter polymorphism tumor necrosis factor (TNF) (-308) is associated with susceptibility to or death from meningococcal sepsis. DESIGN, SETTING, PATIENTS, AND PARTICIPANTS: Association study involving 1321 patients with microbiologically proven invasive meningococcal disease presenting to hospitals throughout United Kingdom during 1998-2001, among whom 134 died. Controls were...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19242354
DOI: 10.1097/CCM.0b013e31819c39bc

Genes

TNF
CCHCR1
NOTCH4
LST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The tumor necrosis factor polymorphism TNF (-308) is associated with susceptibility to meningococcal sepsis, but not with lethality.PMID 19242354Read ↗

Genetic variation in pro-inflammatory cytokines and meningococcal sepsis.Semantic proximity Read ↗

Inherited variability of tumor necrosis factor production and susceptibility to infectious disease.Semantic proximity Read ↗

Genetic variation in the TNF gene is associated with susceptibility to severe sepsis, but not with mortality.Semantic proximity Read ↗

-308 tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter.Semantic proximity Read ↗

Tumor necrosis factor -308 polymorphism (rs1800629) is associated with mortality and ventilator duration in 1057 Caucasian patients.Semantic proximity Read ↗

Mortality in adult intensive care patients with severe systemic inflammatory response syndromes is strongly associated with the hypo-immune TNF -238A polymorphism.Semantic proximity Read ↗

Genetic polymorphisms within tumor necrosis factor gene promoter region: a role for susceptibility to ventilator-associated pneumonia.Semantic proximity Read ↗

Tumor necrosis factor alpha -308 gene locus promoter polymorphism: an analysis of association with health and disease.Semantic proximity Read ↗

Genetic determinants of the inflammatory response.Semantic proximity Read ↗

Association between lymphotoxin-alpha (tumor necrosis factor-beta) intron polymorphism and predisposition to severe sepsis is modified by gender and age.Semantic proximity Read ↗

The TNF-α (-238 G/A) polymorphism could protect against development of severe sepsis.Semantic proximity Read ↗

Association of tumor necrosis factor-alpha-308 (G-->A) polymorphism and susceptibility to brucellosis.Semantic proximity Read ↗

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