Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of tumour necrosis factor-alpha genetic variants and mRNA expression in patients with severe sepsis.

International journal of immunogenetics - 1 Aug 2008

O'Dwyer M J, Mankan A K, Ryan A W, Lawless M W, Stordeur P, Kelleher D, McManus R, Ryan T

Abstract excerpt

Tumour necrosis factor-alpha (TNFalpha) has been implicated in the pathogenicity of severe sepsis by both genetic association studies and animal models. Conflicting functional data have emerged in relation to genetic variants and TNFalpha protein production. Therefore, we assessed the functionality of TNFalpha genetic variants in terms of mRNA production and their potential influence on outcome in the setting of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Haplotypes

Share to RNA, Messenger

Share to Sepsis

Share to Tumor Necrosis Factor-alpha

Share to Young Adult

Source

Identifiers

PMID: 18643840
DOI: 10.1111/j.1744-313X.2008.00773.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of tumour necrosis factor-alpha genetic variants and mRNA expression in patients with severe sepsis.PMID 18643840Read ↗

Evaluation of TNF-α genetic polymorphisms as predictors for sepsis susceptibility and progression.Semantic proximity Read ↗

The G-->A single nucleotide polymorphism at the -308 position in the tumor necrosis factor-alpha promoter increases the risk for severe sepsis after trauma.Semantic proximity Read ↗

Genetic determinants of the inflammatory response.Semantic proximity Read ↗

TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study.Semantic proximity Read ↗

Genetic variation in the TNF gene is associated with susceptibility to severe sepsis, but not with mortality.Semantic proximity Read ↗

Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy.Semantic proximity Read ↗

Genomic polymorphisms in sepsisSemantic proximity Read ↗

Genetic polymorphisms and sepsis.Semantic proximity Read ↗

The TNF-α (-238 G/A) polymorphism could protect against development of severe sepsis.Semantic proximity Read ↗

Cytokine promoter polymorphisms in severe sepsis.Semantic proximity Read ↗

Role of Tumour Necrosis Factor-Alpha promoter 308A/G polymorphism in sepsis and sepsis mortality: A Meta-AnalysisSemantic proximity Read ↗

-308 tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.