Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor necrosis factor gene polymorphism results in high TNF level in sepsis and septic shock.

Cytokine - 1 Feb 2013

Kothari Nikhil, Bogra Jaishri, Abbas Haider, Kohli Monica, Malik Anita, Kothari Divya, Srivastava Shivani, Singh Prithvi K

Abstract excerpt

INTRODUCTION: Systemic sepsis releases several cytokines among which tumor necrosis factor alfa (TNFα) has emerged as key cytokine causing septic shock. Single Nucleotide Polymorphisms (SNPs) at positions -238, -308, -376 and +489 in the promoter region of TNF gene exhibit differential association to inflammation and increased TNF production in sepsis. MATERIALS AND METHODS: This research work was carried out in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Demography
Share to Electrophoresis, Agar Gel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Hospitalization

Share to Intensive Care Units

Share to Polymorphism, Single Nucleotide

Share to Shock, Septic

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 23317877
DOI: 10.1016/j.cyto.2012.11.016

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor necrosis factor gene polymorphism results in high TNF level in sepsis and septic shock.PMID 23317877Read ↗

The TNF-α (-238 G/A) polymorphism could protect against development of severe sepsis.Semantic proximity Read ↗

Role of Tumour Necrosis Factor-Alpha promoter 308A/G polymorphism in sepsis and sepsis mortality: A Meta-AnalysisSemantic proximity Read ↗

Evaluation of TNF-α genetic polymorphisms as predictors for sepsis susceptibility and progression.Semantic proximity Read ↗

Does tumor necrosis factor alpha promoter -308 A/G polymorphism has any role in the susceptibility to sepsis and sepsis risk? A meta-analysis.Semantic proximity Read ↗

Genetic variation in the TNF gene is associated with susceptibility to severe sepsis, but not with mortality.Semantic proximity Read ↗

Tumor necrosis factor-α -308G/A and -238G/A polymorphisms are associated with increased risks of sepsis: evidence from an updated meta-analysis.Semantic proximity Read ↗

Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy.Semantic proximity Read ↗

TNF -308G > a promoter polymorphism (rs1800629) and outcome from critical illness.Semantic proximity Read ↗

Tumour Necrosis Factor-alpha and Nuclear Factor-kappa B Gene Variants in SepsisSemantic proximity Read ↗

TNF-α, IL-6, and IL-8 cytokines and their association with TNF-α-308 G/A polymorphism and postoperative sepsis.Semantic proximity Read ↗

[The associations of the single nucleotide polymorphisms on TNF and CD14 promoters with the mortality of infection, systematic inflammatory response syndromec and sepsis in surgical patients].Semantic proximity Read ↗

Variants in TNF and NOS3 (eNOS) genes associated with sepsis in adult patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.