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Article

Identification and characterization of ispA, a Shigella flexneri chromosomal gene essential for normal in vivo cell division and intracellular spreading.

Molecular microbiology - 1 Feb 1996

Mac Síomóin R A, Nakata N, Murai T, Yoshikawa M, Tsuji H, Sasakawa C

Abstract excerpt

The virulent phenotype of Shigella requires loci on the chromosome as well as on the large virulence plasmid, and is regulated via a complex web of interactions amongst various chromosomal and large plasmid genes. To further investigate the role of chromosomal loci in virulence, we performed random Tn10 mutagenesis in Shigella flexneri YSH6000T, and isolated an avirulent mutant (V3404) incapable of spreading...

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Identifiers

PMID: 8830250
DOI: 10.1046/j.1365-2958.1996.405941.x

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Identification and characterization of ispA, a Shigella flexneri chromosomal gene essential for normal in vivo cell division and intracellular spreading.PMID 8830250Read ↗

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