Article
Cleavage of Shigella surface protein VirG occurs at a specific site, but the secretion is not essential for intracellular spreading.
Journal of bacteriology - 1 Apr 1995
Fukuda I, Suzuki T, Munakata H, Hayashi N, Katayama E, Yoshikawa M, Sasakawa C
Abstract excerpt
The large plasmid-encoded outer membrane protein VirG (IcsA) of Shigella flexneri is essential for bacterial spreading by eliciting polar deposition of filamentous actin (F-actin) in the cytoplasm of epithelial cells. Recent studies have indicated that VirG is located at one pole on the surface of the bacterium and secreted into the culture supernatant and that in host cells it is localized along the length of...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- DNA-Binding Proteins
- Molecular Sequence Data
- Mutation
- Plasmids
- Shigella
- Transcription Factors