Article
Identification and characterization of a chromosomal virulence gene, <i>vacJ</i>, required for intercellular spreading of <i>Shigella flexneri</i>
1 Jan 1994
Abstract excerpt
Intercellular spreading of shigellae is a prerequisite for shigellosis, although the molecular mechanisms underlying the phenomenon are still largely obscure. To elucidate some of these mechanisms, we performed random Tn10 insertion mutagenesis in Shigella flexneri YSH6000T and found a chromosomal locus in the NotI-J segment responsible for bacterial spreading. The locus affected in the mutant, designated vacJ,...
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