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[Multiple drug resistance].

Lijecnicki vjesnik - 1 Jan 2000

Svoboda-Beusan I

Abstract excerpt

The multidrug-resistance (MDR) phenotype expressed in mammalian cell lines is complex. A cell selected with a single agent can acquire cross-resistance to a remarkably wide range of compounds which have no structural or functional similarities. The basis for cross-resistance seems to be a decreased net cellular accumulation of the drugs involved, and has been attributed to alterations in plasma membrane. An...

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PMID: 8028439

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