Article
[Correlation between MDR1 genetic polymorphism and prognosis in acute myeloid leukemia].
Zhonghua yi xue za zhi - 29 May 2007
Wang Dan, Ke Xiao-yan, Wang Jing, Xu Fang, Hu Yong-fang
Abstract excerpt
OBJECTIVE: To assess the correlation of the multidrug resistance-1 (MDR1) gene single nucleotide polymorphisms (SNP) C1236T, G2677T/A and C3435T with the outcome of induction chemotherapy in patients with de novo acute myeloid leukemia (AML). METHODS: A total of 44 AML patients were enrolled in this study. Genotype of MDR1 C1236T, G2677T/A and C3435T were analyzed with PCR/PFLP assay. Bone marrow smear was made...
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