Article
Structural and functional analysis of beta2 microglobulin abnormalities in human lung and breast cancer.
International journal of cancer - 17 Sept 1996
Chen H L, Gabrilovich D, Virmani A, Ratnani I, Girgis K R, Nadaf-Rahrov S, Fernandez-Viña M, Carbone D P
Abstract excerpt
The escape of tumor cells from immune recognition is a central problem in tumor immunology. Here, we examined the functional role of somatic beta 2-microglobulin (beta2m) gene mutations in human lung and breast cancers. Using single-strand conformational polymorphism (SSCP) analysis and DNA sequencing, we found mutations in the beta2m gene in 2 of 110 tested lung, colon and breast tumors and tumor cell lines. No...
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