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Article

Decipher β2-microglobulin: gain- or loss-of-function (a mini-review).

Medical science monitor basic research - 21 Oct 2013

Chiou Shean-Jaw, Chen Chang-Han

Abstract excerpt

β2-microglobulin (β2M) functions as a chaperon to maintain structural stability of MHC class I complex that is associated with antigen presentation to cytotoxic (CD8+) T lymphocytes. Cancerous cells in β2M loss-of-function are thought to avoid immune surveillance. As increased level of β2M present in tissue/serum is significantly associated with tumor status in various cancers, β2M may become an important...

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Identifiers

PMID: 24146000
DOI: 10.12659/MSMBR.889457
PMCID: PMC3853100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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