Mutants of human beta2-microglobulin map an immunodominant epitope within the three-stranded beta-pleated sheet.

doi:10.1097/00007890-199708270-00016

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Article

Mutants of human beta2-microglobulin map an immunodominant epitope within the three-stranded beta-pleated sheet.

Transplantation - 27 Aug 1997

Trymbulak W P, Zeff R A

Abstract excerpt

Genetically engineered structural variants of human beta2-microglobulin (beta2m) were produced by sequence exchange with mouse beta2m for the purpose of examining species-specific antigenic determinant expression. For aggregate mapping, mouse and human beta2m, which differ by 30% in their primary...

Topics

Animals
Cell Line
Chromosome Mapping
Flow Cytometry
Humans
Immunodominant Epitopes
Mice
Mutation
Protein Conformation
beta 2-Microglobulin

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