Article
Lack and restoration of sensitivity of lung cancer cells to cellular attack with special reference to expression of human leukocyte antigen class I and/or major histocompatibility complex class I chain related molecules A/B.
Cancer science - 1 Nov 2007
Baba Tetsuro, Hanagiri Takeshi, Ichiki Yoshinobu, Kuroda Koji, Shigematsu Yoshiki, Mizukami Makiko, Sugaya Masakazu, Takenoyama Mitsuhiro, Sugio Kenji, Yasumoto Kosei
Abstract excerpt
Both cytotoxic T lymphocytes (CTL) and natural killer (NK) cells may play major roles in the host defense against cancer. However, their relationship against the same tumor remains to be elucidated. Among 26 human lung cancer cell lines established in our laboratory, 10 (38%) exhibited human leukocyte antigen (HLA)-class I haplotype loss and three (12%) lost HLA-class I expression totally by flow cytometry...
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