Article
A mutant human beta2-microglobulin can be used to generate diverse multimeric class I peptide complexes as specific probes for T cell receptors.
Journal of immunological methods - 1 May 1998
Walter J B, Garboczi D N, Fan Q R, Zhou X, Walker B D, Eisen H N
Abstract excerpt
Antigen-specific receptors (TCR) on CD8 T lymphocytes form relatively short-lived complexes with their natural ligands: peptides in association with major histocompatibility complex (MHC) class I molecules, which consist of a polymorphic heavy chain and a conserved light chain, beta2-microglobuli...
Topics
- Animals
- Binding Sites
- Biotin
- Fluorescent Dyes
- Histocompatibility Antigens Class I
- Humans
- Immunoglobulin Heavy Chains
- Mice
- Mutation
- Peptides
- Receptors, Antigen, T-Cell
- Substrate Specificity
- beta 2-Microglobulin