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Article

Modification of Schwann cell phenotype with Plp transgenes: evidence that the PLP and DM20 isoproteins are targeted to different cellular domains.

Journal of neuroscience research - 1 Oct 1997

Anderson T J, Montague P, Nadon N, Nave K A, Griffiths I R

Abstract excerpt

The X-linked proteolipid protein (Plp) gene encodes PLP, the major protein of central nervous system myelin, and its alternative RNA splice product, termed DM20. Schwann cells also express the Plp gene but, in contrast to oligodendrocytes, neither protein is incorporated into peripheral myelin. I...

Topics

Animals
Biological Transport
Brain Chemistry
Cell Compartmentation
Gene Dosage
Gene Expression
Mice
Mice, Transgenic
Myelin Proteolipid Protein
Myelin Sheath
Nerve Tissue Proteins
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Conformation

Protein Structure, Tertiary

Schwann Cells

Sciatic Nerve

Transgenes

Source

Identifiers

PMID: 9379489
DOI: 10.1002/(SICI)1097-4547(19971001)50:1<13::AID-JNR2>3.0.CO;2-O

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9379489-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Modification of Schwann cell phenotype with Plp transgenes: evidence that the PLP and DM20 isoproteins are targeted to different cellular domains.PMID 9379489Read ↗

A combination of PLP and DM20 transgenes promotes partial myelination in the jimpy mouse.Semantic proximity Read ↗

Transgenic and natural mouse models of proteolipid protein (PLP)-related dysmyelination and demyelination.Semantic proximity Read ↗

Current concepts of PLP and its role in the nervous system.Semantic proximity Read ↗

Epigenetic factors up-regulate expression of myelin proteins in the dysmyelinating jimpy mutant mouse.Semantic proximity Read ↗

Phenotypic severity of murine Plp mutants reflects in vivo and in vitro variations in transport of PLP isoproteins.Semantic proximity Read ↗

The pathobiology of myelin mutants reveal novel biological functions of the MBP and PLP genes.Semantic proximity Read ↗

Rumpshaker-like proteolipid protein (PLP) ratio in a mouse model with unperturbed structural and functional integrity of the myelin sheath and axons in the central nervous system.Semantic proximity Read ↗

Conservative amino acid substitution in the myelin proteolipid protein of jimpymsd mice.Semantic proximity Read ↗

The proteolipid protein gene and myelin disorders in man and animal models.Semantic proximity Read ↗

Jimpy-4J mouse has a missense mutation in exon 2 of the Plp gene.Semantic proximity Read ↗

Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene.Semantic proximity Read ↗

The absence of myelin P0 protein produces a novel molecular phenotype in Schwann cells.Semantic proximity Read ↗

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