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Article

Modification of Schwann cell phenotype with Plp transgenes: evidence that the PLP and DM20 isoproteins are targeted to different cellular domains.

Journal of neuroscience research - 1 Oct 1997

Anderson T J, Montague P, Nadon N, Nave K A, Griffiths I R

Abstract excerpt

The X-linked proteolipid protein (Plp) gene encodes PLP, the major protein of central nervous system myelin, and its alternative RNA splice product, termed DM20. Schwann cells also express the Plp gene but, in contrast to oligodendrocytes, neither protein is incorporated into peripheral myelin. In the present study, we use different transgenes encoding PLP and DM20 to modify the expression of these proteins in...

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PMID: 9379489
DOI: 10.1002/(SICI)1097-4547(19971001)50:1<13::AID-JNR2>3.0.CO;2-O

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