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Article

Glial transplants: an in vivo analysis of extrinsic and intrinsic determinants of dysmyelination in genetic variants.

Brain pathology (Zurich, Switzerland) - 1 Jul 1995

Lachapelle F

Abstract excerpt

Myelination in the CNS depends on the ability of oligodendrocytes (Ols) to efficiently colonize the brain, differentiate, and express a precise balance of specific genes necessary for myelin synthesis. Mutations in these genes produce different types of dysmyelination in animal as in human. Defects in the synthesis of myelin constituents usually lead to mild dysmyelinations. IN contrast, mutations affecting the...

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PMID: 8520729
DOI: 10.1111/j.1750-3639.1995.tb00606.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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