Glial transplants: an in vivo analysis of extrinsic and intrinsic determinants of dysmyelination in genetic variants.

doi:10.1111/j.1750-3639.1995.tb00606.x

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Article

Glial transplants: an in vivo analysis of extrinsic and intrinsic determinants of dysmyelination in genetic variants.

Brain pathology (Zurich, Switzerland) - 1 Jul 1995

Lachapelle F

Abstract excerpt

Myelination in the CNS depends on the ability of oligodendrocytes (Ols) to efficiently colonize the brain, differentiate, and express a precise balance of specific genes necessary for myelin synthesis. Mutations in these genes produce different types of dysmyelination in animal as in human. Defec...

Topics

Animals
Demyelinating Diseases
Genes, Dominant
Genetic Variation
Humans
Models, Genetic
Mutation
Myelin Proteolipid Protein
Neuroglia
Phenotype

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