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Article

Gene expression of the human glucagon-like peptide-1 receptor is regulated by Sp1 and Sp3.

Endocrinology - 1 Feb 1999

Wildhage I, Trusheim H, Göke B, Lankat-Buttgereit B

Abstract excerpt

The human glucagon-like peptide-1 (GLP-1) receptor mediates the insulinotropic effects of the incretin hormone GLP-1. It is expressed in a cell- and tissue-specific manner. Recently, we cloned the 5'-region of the GLP-1 receptor gene and found that tissue and cell specificity is lost by 5'-deletion to -574. In this region proximal to the main transcription start point three putative binding sites for Sp1 were...

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PMID: 9927286
DOI: 10.1210/endo.140.2.6512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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