Article
Identification of a pancreatic beta-cell insulin gene transcription factor that binds to and appears to activate cell-type-specific expression: its possible relationship to other cellular factors that bind to a common insulin gene sequence.
Molecular and cellular biology - 1 Apr 1990
Whelan J, Cordle S R, Henderson E, Weil P A, Stein R
Abstract excerpt
The insulin gene is expressed almost exclusively in pancreatic beta-cells. Previous work in our laboratory has shown that pancreatic beta-cell-specific expression of the rat insulin II gene is controlled by a number of positive and negative cis-acting DNA elements within the enhancer. We have shown that one element within the enhancer, located between nucleotides -100 and -91 (GCCATCTGCT; referred to as the...
Topics
- Animals
- Base Sequence
- Cell Line
- Cell Nucleus
- Enhancer Elements, Genetic
- Gene Expression Regulation
- Genes
- HeLa Cells
- Humans
- Insulin