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Article

Human diabetes associated with defects in nuclear regulatory proteins for the insulin receptor gene.

1 Jan 1996

Abstract excerpt

The control of gene transcription is mediated by sequence-specific DNA-binding proteins (trans-acting factors) that bind to upstream regulatory elements (cis elements). We have previously identified two DNA-binding proteins that specifically interact with two unique AT-rich sequences of the 5' regulatory region of the insulin receptor gene which have in vivo promoter activity. Herein we have investigated the...

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Identifiers

PMID: 8550844
DOI: 10.1172/jci118400

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Source receipt: pubmed, retrieved 7 Sept 2026.

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