Article
Transcriptional activity of domain A of the rat glucagon G3 element conferred by an islet-specific nuclear protein that also binds to similar pancreatic islet cell-specific enhancer sequences (PISCES).
Gene expression - 1 Jan 1995
Wrege A, Diedrich T, Hochhuth C, Knepel W
Abstract excerpt
A pancreatic islet cell-specific enhancer element in the rat glucagon gene, Glu-G3, contains two domains, one of which, domain A, has been shown to be necessary for Glu-G3 activity. In the present study, the functions of the isolated domain A of Glu-G3 were investigated by using transient reporte...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cells, Cultured
- DNA-Binding Proteins
- Electrophoresis, Polyacrylamide Gel
- Enhancer Elements, Genetic
- Gene Expression Regulation
- Genes, Reporter
- Glucagon
- Islets of Langerhans
- Luciferases
- Molecular Sequence Data
- Mutation