Article
Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene.
The Journal of biological chemistry - 5 Sept 1991
Shieh S Y, Tsai M J
Abstract excerpt
Pancreatic beta-cell-specific expression of the insulin gene is mediated, at least in part, by an enhancer element termed the rat insulin promoter element 3 (RIPES) found within the rat insulin II gene between positions -126 and -86. Here we identify three distinct factors interacting with RIPE3, namely 3a1, 3a2, and 3b1, which bind to the sequences between -100 to -90, -108 to -99, and -115 to -107,...
Topics
- Animals
- Base Sequence
- Binding Sites
- Binding, Competitive
- Cell Line
- Cricetinae
- DNA
- DNA-Binding Proteins
- Enhancer Elements, Genetic
- HeLa Cells
- Insulin
- Islets of Langerhans