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Article

Pleiotropic nuclear defects associated with a conditional allele of the novel nucleoporin Rat9p/Nup85p.

Molecular biology of the cell - 1 Jun 1996

Goldstein A L, Snay C A, Heath C V, Cole C N

Abstract excerpt

In a screen for mutants defective in nucleocytoplasmic export of mRNA, we have identified a new component of the Saccharomyces cerevisiae nuclear pore complex (NPC). The RAT9/NUP85 (ribonucleic acid trafficking) gene encodes an 84.9-kDa protein that we have localized to NPCs by tagging the RAT9/N...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Genes, Fungal
Membrane Proteins
Molecular Sequence Data
Nuclear Pore Complex Proteins
Nuclear Proteins
Phenotype
Plasmids
RNA, Messenger
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae Proteins

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Open in PubMed Open full text

Identifiers

PMID: 8816998
DOI: 10.1091/mbc.7.6.917
PMCID: PMC275943

Genes

NUP85

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8816998-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Pleiotropic nuclear defects associated with a conditional allele of the novel nucleoporin Rat9p/Nup85p.PMID 8816998Read ↗

Mutation or deletion of the Saccharomyces cerevisiae RAT3/NUP133 gene causes temperature-dependent nuclear accumulation of poly(A)+ RNA and constitutive clustering of nuclear pore complexes.Semantic proximity Read ↗

Nuclear pore complex clustering and nuclear accumulation of poly(A)+ RNA associated with mutation of the Saccharomyces cerevisiae RAT2/NUP120 gene.Semantic proximity Read ↗

Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export.Semantic proximity Read ↗

The product of the Saccharomyces cerevisiae RSS1 gene, identified as a high-copy suppressor of the rat7-1 temperature-sensitive allele of the RAT7/NUP159 nucleoporin, is required for efficient mRNA export.Semantic proximity Read ↗

A novel nuclear pore protein Nup133p with distinct roles in poly(A)+ RNA transport and nuclear pore distribution.Semantic proximity Read ↗

Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells.Semantic proximity Read ↗

A structure/function analysis of Rat7p/Nup159p, an essential nucleoporin of Saccharomyces cerevisiae.Semantic proximity Read ↗

Synthetic genetic array analysis in Saccharomyces cerevisiae provides evidence for an interaction between RAT8/DBP5 and genes encoding P-body components.Semantic proximity Read ↗

Isolation and characterization of RAT1: an essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.Semantic proximity Read ↗

NNF1 is an essential yeast gene required for proper spindle orientation, nucleolar and nuclear envelope structure and mRNA export.Semantic proximity Read ↗

ER membrane-bending proteins are necessary for de novo nuclear pore formation.Semantic proximity Read ↗

Yeast nucleoporin mutants are defective in pre-tRNA splicing.Semantic proximity Read ↗

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