Yeast nucleoporin mutants are defective in pre-tRNA splicing.

doi:10.1128/MCB.16.1.294

Back to search

Article

Yeast nucleoporin mutants are defective in pre-tRNA splicing.

Molecular and cellular biology - 1 Jan 1996

Sharma K, Fabre E, Tekotte H, Hurt E C, Tollervey D

Abstract excerpt

We have screened nucleoporin mutants for the inhibition of tRNA splicing, which has previously been proposed to be coupled to transport. Strains mutant for Nup49p or Nup116p, or genetically depleted of Nup145p, strongly accumulated unspliced pre-tRNAs. Splicing was inhibited for all 10 families o...

Topics

Base Sequence
DNA, Fungal
Fungal Proteins
Membrane Proteins
Molecular Sequence Data
Mutation
Nuclear Envelope
Nuclear Proteins
RNA Precursors
RNA Splicing
RNA, Fungal
Saccharomyces cerevisiae

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.