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Article

Yeast nucleoporin mutants are defective in pre-tRNA splicing.

Molecular and cellular biology - 1 Jan 1996

Sharma K, Fabre E, Tekotte H, Hurt E C, Tollervey D

Abstract excerpt

We have screened nucleoporin mutants for the inhibition of tRNA splicing, which has previously been proposed to be coupled to transport. Strains mutant for Nup49p or Nup116p, or genetically depleted of Nup145p, strongly accumulated unspliced pre-tRNAs. Splicing was inhibited for all 10 families of intron-containing pre-tRNA, but no effects on 5' or 3' end processing were detected. Strains mutant for Nup133p or...

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Identifiers

PMID: 8524308
DOI: 10.1128/MCB.16.1.294
PMCID: PMC231003

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