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Article

A structure/function analysis of Rat7p/Nup159p, an essential nucleoporin of Saccharomyces cerevisiae.

Journal of cell science - 1 Dec 1997

Del Priore V, Heath C, Snay C, MacMillan A, Gorsch L, Dagher S, Cole C

Abstract excerpt

Rat7p/Nup159p is an essential nucleoporin of Sac-charomyces cerevisiae originally isolated in a genetic screen designed to identify yeast temperature-sensitive mutants defective in mRNA export. Here we describe a detailed structural-functional analysis of Rat7p/Nup159p. The mutation in the rat7-1...

Topics

Alleles
Amino Acid Substitution
Fungal Proteins
Genes, Fungal
Kinetics
Membrane Proteins
Mutagenesis, Site-Directed
Nuclear Pore Complex Proteins
Nuclear Proteins
Polymerase Chain Reaction
RNA, Fungal
Repetitive Sequences, Nucleic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Sequence Deletion

Source

Identifiers

PMID: 9359887
DOI: 10.1242/jcs.110.23.2987

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9359887-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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A structure/function analysis of Rat7p/Nup159p, an essential nucleoporin of Saccharomyces cerevisiae.PMID 9359887Read ↗

The product of the Saccharomyces cerevisiae RSS1 gene, identified as a high-copy suppressor of the rat7-1 temperature-sensitive allele of the RAT7/NUP159 nucleoporin, is required for efficient mRNA export.Semantic proximity Read ↗

Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells.Semantic proximity Read ↗

Pleiotropic nuclear defects associated with a conditional allele of the novel nucleoporin Rat9p/Nup85p.Semantic proximity Read ↗

Mutation or deletion of the Saccharomyces cerevisiae RAT3/NUP133 gene causes temperature-dependent nuclear accumulation of poly(A)+ RNA and constitutive clustering of nuclear pore complexes.Semantic proximity Read ↗

Functional characterization of a Nup159p-containing nuclear pore subcomplex.Semantic proximity Read ↗

Members of the RSC chromatin-remodeling complex are required for maintaining proper nuclear envelope structure and pore complex localization.Semantic proximity Read ↗

The fission yeast Nup107-120 complex functionally interacts with the small GTPase Ran/Spi1 and is required for mRNA export, nuclear pore distribution, and proper cell division.Semantic proximity Read ↗

Structure and assembly of the Nup84p complex.Semantic proximity Read ↗

Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export.Semantic proximity Read ↗

The yeast splicing factor Prp40p contains functional leucine-rich nuclear export signals that are essential for splicing.Semantic proximity Read ↗

Synthetic genetic array analysis in Saccharomyces cerevisiae provides evidence for an interaction between RAT8/DBP5 and genes encoding P-body components.Semantic proximity Read ↗

A novel nuclear pore protein Nup133p with distinct roles in poly(A)+ RNA transport and nuclear pore distribution.Semantic proximity Read ↗

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