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Article

ER membrane-bending proteins are necessary for de novo nuclear pore formation.

The Journal of cell biology - 9 Mar 2009

Dawson T Renee, Lazarus Michelle D, Hetzer Martin W, Wente Susan R

Abstract excerpt

Nucleocytoplasmic transport occurs exclusively through nuclear pore complexes (NPCs) embedded in pores formed by inner and outer nuclear membrane fusion. The mechanism for de novo pore and NPC biogenesis remains unclear. Reticulons (RTNs) and Yop1/DP1 are conserved membrane protein families required to form and maintain the tubular endoplasmic reticulum (ER) and the postmitotic nuclear envelope. In this study, we...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19273614
DOI: 10.1083/jcb.200806174
PMCID: PMC2686408

Genes

RTN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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