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Article

The transcription factor Swi5 regulates expression of the cyclin kinase inhibitor p40SIC1.

Molecular and cellular biology - 1 Oct 1996

Knapp D, Bhoite L, Stillman D J, Nasmyth K

Abstract excerpt

DNA replication in budding yeast cells depends on the activation of the Cdc28 kinase (Cdk1 of Saccharomyces cerevisiae) associated with B-type cyclins Clb1 to Clb6. Activation of the kinase depends on proteolysis of the Cdk inhibitor p40SIC1 in late G1, which is mediated by the ubiquitin-conjugating enzyme Cdc34 and two other proteins, Cdc4 and Cdc53. Inactivation of any one of these three proteins prevents...

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Source

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Identifiers

PMID: 8816483
DOI: 10.1128/MCB.16.10.5701
PMCID: PMC231570

Genes

RIC3
SWI5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The transcription factor Swi5 regulates expression of the cyclin kinase inhibitor p40SIC1.PMID 8816483Read ↗

The Swi5 transcription factor of Saccharomyces cerevisiae has a role in exit from mitosis through induction of the cdk-inhibitor Sic1 in telophase.Semantic proximity Read ↗

The Cdk inhibitors p25rum1 and p40SIC1 are functional homologues that play similar roles in the regulation of the cell cycle in fission and budding yeast.Semantic proximity Read ↗

Functional connection between the Clb5 cyclin, the protein kinase C pathway and the Swi4 transcription factor in Saccharomyces cerevisiae.Semantic proximity Read ↗

Coordinated regulation of gene expression by the cell cycle transcription factor Swi4 and the protein kinase C MAP kinase pathway for yeast cell integrity.Semantic proximity Read ↗

A genetic screen reveals a role for the late G1-specific transcription factor Swi4p in diverse cellular functions including cytokinesis.Semantic proximity Read ↗

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.Semantic proximity Read ↗

A role for Ctr9p and Paf1p in the regulation G1 cyclin expression in yeast.Semantic proximity Read ↗

Multiple pathways for suppression of mutants affecting G1-specific transcription in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cell cycle regulators interact with pathways that modulate microtubule stability in Saccharomyces cerevisiae.Semantic proximity Read ↗

Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase.Semantic proximity Read ↗

Cell cycle-regulated phosphorylation of Swi6 controls its nuclear localization.Semantic proximity Read ↗

Rme1, which controls CLN2 expression in Saccharomyces cerevisiae, is a nuclear protein that is cell cycle regulated.Semantic proximity Read ↗

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