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Article

Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase.

Science (New York, N.Y.) - 17 Oct 1997

Verma R, Annan R S, Huddleston M J, Carr S A, Reynard G, Deshaies R J

Abstract excerpt

G1 cyclin-dependent kinase (Cdk)-triggered degradation of the S-phase Cdk inhibitor Sic1p has been implicated in the transition from G1 to S phase in the cell cycle of budding yeast. A multidimensional electrospray mass spectrometry technique was used to map G1 Cdk phosphorylation sites in Sic1p...

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Identifiers

PMID: 9334303
DOI: 10.1126/science.278.5337.455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9334303-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase.PMID 9334303Read ↗

Selective degradation of ubiquitinated Sic1 by purified 26S proteasome yields active S phase cyclin-Cdk.Semantic proximity Read ↗

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.Semantic proximity Read ↗

The Dcr2p phosphatase destabilizes Sic1p in Saccharomyces cerevisiae.Semantic proximity Read ↗

Identification of YPL014W (Cip1) as a novel negative regulator of cyclin-dependent kinase in Saccharomyces cerevisiae.Semantic proximity Read ↗

The transcription factor Swi5 regulates expression of the cyclin kinase inhibitor p40SIC1.Semantic proximity Read ↗

Distinct activities of the related protein kinases Cdk1 and Ime2.Semantic proximity Read ↗

Molecular systems biology of Sic1 in yeast cell cycle regulation through multiscale modeling.Semantic proximity Read ↗

The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain.Semantic proximity Read ↗

Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus.Semantic proximity Read ↗

The Cdc6 protein is ubiquitinated in vivo for proteolysis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets.Semantic proximity Read ↗

The Cdk inhibitors p25rum1 and p40SIC1 are functional homologues that play similar roles in the regulation of the cell cycle in fission and budding yeast.Semantic proximity Read ↗

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