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Article

Functional connection between the Clb5 cyclin, the protein kinase C pathway and the Swi4 transcription factor in Saccharomyces cerevisiae.

Genetics - 1 Dec 2005

Queralt Ethel, Igual J Carlos

Abstract excerpt

The rsf12 mutation was isolated in a synthetic lethal screen for genes functionally interacting with Swi4. RSF12 is CLB5. The clb5 swi4 mutant cells arrest at G(2)/M due to the activation of the DNA-damage checkpoint. Defects in DNA integrity was confirmed by the increased rates of chromosome loss and mitotic recombination. Other results suggest the presence of additional defects related to morphogenesis....

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Identifiers

PMID: 16118191
DOI: 10.1534/genetics.105.045005
PMCID: PMC1456078

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