Reevaluation of 3'Ekappa function in stage- and lineage-specific rearrangement and somatic hypermutation.

doi:10.1016/s1074-7613(00)80579-8

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Article

Reevaluation of 3'Ekappa function in stage- and lineage-specific rearrangement and somatic hypermutation.

Immunity - 1 Jun 1998

van der Stoep N, Gorman J R, Alt F W

Abstract excerpt

Transgenic studies have led to the conclusion that the 3'Ekappa enhancer functions to suppress kappa variable region gene assembly in T lineage cells and in progenitor B cells and have also implicated 3'Ekappa as a critical element in promoting somatic hypermutation of kappa variable region genes...

Topics

Animals
Base Sequence
Cell Lineage
Gene Rearrangement, T-Lymphocyte
Genes, Immunoglobulin
Immunoglobulin Variable Region
Immunoglobulin kappa-Chains
Mice
Mice, Transgenic
Molecular Sequence Data
Mutation
T-Lymphocytes

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