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Article

Reevaluation of 3'Ekappa function in stage- and lineage-specific rearrangement and somatic hypermutation.

Immunity - 1 Jun 1998

van der Stoep N, Gorman J R, Alt F W

Abstract excerpt

Transgenic studies have led to the conclusion that the 3'Ekappa enhancer functions to suppress kappa variable region gene assembly in T lineage cells and in progenitor B cells and have also implicated 3'Ekappa as a critical element in promoting somatic hypermutation of kappa variable region genes. To assess the role of the endogenous 3'Ekappa, we assayed these processes in mice homozygous for mutations in which...

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Identifiers

PMID: 9655488
DOI: 10.1016/s1074-7613(00)80579-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Reevaluation of 3'Ekappa function in stage- and lineage-specific rearrangement and somatic hypermutation.PMID 9655488Read ↗

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