Article
Rapamycin resistance in ataxia-telangiectasia.
Oncogene - 5 Sept 1996
Beamish H, Williams R, Chen P, Khanna K K, Hobson K, Watters D, Shiloh Y, Lavin M
Abstract excerpt
The gene mutated in the human genetic disorder ataxia-telangiectasia (A-T) has been described recently (Savitsky et al., 1995a) and the complete coding sequence of this gene, ATM, has been reported (Savitsky et al., 1995b). The derived amino acid sequence demonstrates significant homologies to several proteins containing a phosphatidylinositol 3-kinase (PI3-kinase) domain, including the yeast TOR proteins and the...
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