Article
Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.
Molecular and cellular biology - 1 Oct 1993
Cafferkey R, Young P R, McLaughlin M M, Bergsma D J, Koltin Y, Sathe G M, Faucette L, Eng W K, Johnson R K, Livi G P
Abstract excerpt
Rapamycin is a macrolide antifungal agent that exhibits potent immunosuppressive properties. In Saccharomyces cerevisiae, rapamycin sensitivity is mediated by a specific cytoplasmic receptor which is a homolog of human FKBP12 (hFKBP12). Deletion of the gene for yeast FKBP12 (RBP1) results in recessive drug resistance, and expression of hFKBP12 restores rapamycin sensitivity. These data support the idea that...
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