Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.

doi:10.1126/science.1715094

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Article

Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.

Science (New York, N.Y.) - 23 Aug 1991

Heitman J, Movva N R, Hall M N

Abstract excerpt

FK506 and rapamycin are related immunosuppressive compounds that block helper T cell activation by interfering with signal transduction. In vitro, both drugs bind and inhibit the FK506-binding protein (FKBP) proline rotamase. Saccharomyces cerevisiae cells treated with rapamycin irreversibly arrested in the G1 phase of the cell cycle. An FKBP-rapamycin complex is concluded to be the toxic agent because (i)...

Topics

Amino Acid Sequence
Anti-Bacterial Agents
Base Sequence
Binding Sites
Carrier Proteins
Cell Cycle
Cyclosporins
Drug Resistance, Microbial
G1 Phase
Humans
Immunosuppressive Agents
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Structure

Mutation

Polyenes

Saccharomyces cerevisiae

Sequence Homology, Nucleic Acid

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 1715094
DOI: 10.1126/science.1715094

Genes

FPR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1715094-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.PMID 1715094Read ↗

TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.Semantic proximity Read ↗

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A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus.Semantic proximity Read ↗

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