Article
Altered centrosomes in ataxia-telangiectasia cells and rapamycin-treated Chinese hamster cells.
Environmental and molecular mutagenesis - 1 Oct 2005
Bonatti Stefania, Simili Marcella, Benedetti Pier Alberto, Morandi Fabio, Menichini Paola, Del Carratore Renata, Barale Roberto, Abbondandolo Angelo
Abstract excerpt
Rapamycin induces chromosome malsegregation in mammalian cell lines and yeast. Previous studies indicate that the function impaired in ataxia-telangiectasia (A-T) patients is necessary for both the growth inhibition and the chromosome malsegregation induced by rapamycin, and that treating the non-tumorigenic Chinese hamster cell line CHEF/18 with rapamycin results in supernumerary centrosomes and multipolar...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.