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Article

Missense mutations at the FKBP12-rapamycin-binding site of TOR1.

Gene - 12 Jun 1996

Freeman K, Livi G P

Abstract excerpt

The TOR genes were first identified in Saccharomyces cerevisiae by the isolation of mutants which exhibit dominant resistance to the immunosuppressive and antifungal drug rapamycin (Rm). The originally characterized Rm-resistant (RmR) TOR1-1 and TOR2-1 alleles contain an Arg in place of a conserved Ser residue, which lies adjacent to the phosphatidylinositol (PI) kinase-related domain of TOR (Ser1972 in TOR1;...

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Identifiers

PMID: 8654975
DOI: 10.1016/0378-1119(96)00168-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Missense mutations at the FKBP12-rapamycin-binding site of TOR1.PMID 8654975Read ↗

TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.Semantic proximity Read ↗

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.Semantic proximity Read ↗

Yeast TOR (DRR) proteins: amino-acid sequence alignment and identification of structural motifs.Semantic proximity Read ↗

The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine.Semantic proximity Read ↗

Caffeine targets TOR complex I and provides evidence for a regulatory link between the FRB and kinase domains of Tor1p.Semantic proximity Read ↗

Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast.Semantic proximity Read ↗

The tyrosine89 residue of yeast FKBP12 is required for rapamycin binding.Semantic proximity Read ↗

Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.Semantic proximity Read ↗

Chemical Genetics of Rapamycin-Insensitive TORC2 in S. cerevisiaeSemantic proximity Read ↗

Rapamycin Antifungal Action Is Mediated via Conserved Complexes with FKBP12 and TOR Kinase Homologs in Cryptococcus neoformansSemantic proximity Read ↗

The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin.Semantic proximity Read ↗

Antifungal properties of the immunosuppressant FK-506: identification of an FK-506-responsive yeast gene distinct from FKB1.Semantic proximity Read ↗

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