Missense mutations at the FKBP12-rapamycin-binding site of TOR1.

doi:10.1016/0378-1119(96)00168-0

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Missense mutations at the FKBP12-rapamycin-binding site of TOR1.

Gene - 12 Jun 1996

Freeman K, Livi G P

Abstract excerpt

The TOR genes were first identified in Saccharomyces cerevisiae by the isolation of mutants which exhibit dominant resistance to the immunosuppressive and antifungal drug rapamycin (Rm). The originally characterized Rm-resistant (RmR) TOR1-1 and TOR2-1 alleles contain an Arg in place of a conserv...

Topics

Base Sequence
Binding Sites
Carrier Proteins
DNA Primers
DNA-Binding Proteins
Fungal Proteins
Heat-Shock Proteins
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Phosphatidylinositol 3-Kinases
Phosphorylation
Phosphotransferases (Alcohol Group Acceptor)
Polyenes
Saccharomyces cerevisiae Proteins
Sirolimus
Tacrolimus Binding Proteins

Source

Open in PubMed

Identifiers

PMID: 8654975
DOI: 10.1016/0378-1119(96)00168-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8654975-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics