Multifactor cis-dominant negative regulation of IL-2 gene expression in anergized T cells.

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Article

Multifactor cis-dominant negative regulation of IL-2 gene expression in anergized T cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 1996

Kitagawa-Sakakida S, Schwartz R H

Abstract excerpt

The molecular mechanism underlying IL-2 transcriptional blockade in anergic T cell clones is not fully understood. To examine whether an active negative regulatory process occurs, we created a reporter construct containing as an enhancer four copies of the NF-AT site and one copy of the octamer s...

Topics

Animals
Antibodies, Monoclonal
Clonal Anergy
Clone Cells
Enhancer Elements, Genetic
Gene Expression Regulation
Genes, Reporter
Humans
Interleukin-2
Mice
Mutation
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocytes
Transcription Factor AP-1
Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 8805630

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8805630-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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