Article
c-Rel phenocopies PKCtheta but not Bcl-10 in regulating CD8+ T-cell activation versus tolerance.
European journal of immunology - 1 Mar 2010
Deenick Elissa K, Po Leslie, Chapatte Laurence, Murakami Kiichi, Lu Yong-Chen, Elford Alisha R, Saibil Samuel D, Ruland Jürgen, Gerondakis Steve, Mak Tak W, Ohashi Pamela S
Abstract excerpt
Elucidating the signaling events that promote T-cell tolerance versus activation provides important insights for manipulating immunity in vivo. Previous studies have suggested that the absence of PKCtheta results in the induction of anergy and that the balance between the induction of the transcr...
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