Article
Transactivation by AP-1 is a molecular target of T cell clonal anergy.
Science (New York, N.Y.) - 21 Aug 1992
Kang S M, Beverly B, Tran A C, Brorson K, Schwartz R H, Lenardo M J
Abstract excerpt
Anergy is a mechanism of T lymphocyte tolerance induced by antigen receptor stimulation in the absence of co-stimulation. Anergic T cells were shown to have a defect in antigen-induced transcription of the interleukin-2 gene. Analysis of the promoter indicated that the transcription factor AP-1 a...
Topics
- Animals
- Antigen-Presenting Cells
- Antigens
- Base Sequence
- Binding Sites
- Blotting, Northern
- Cell Line
- Concanavalin A
- Gene Expression Regulation
- Immune Tolerance
- Interleukin-2
- Mice
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Proto-Oncogene Proteins c-jun
- RNA, Messenger
- Receptors, Antigen, T-Cell