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Article

Transactivation by AP-1 is a molecular target of T cell clonal anergy.

Science (New York, N.Y.) - 21 Aug 1992

Kang S M, Beverly B, Tran A C, Brorson K, Schwartz R H, Lenardo M J

Abstract excerpt

Anergy is a mechanism of T lymphocyte tolerance induced by antigen receptor stimulation in the absence of co-stimulation. Anergic T cells were shown to have a defect in antigen-induced transcription of the interleukin-2 gene. Analysis of the promoter indicated that the transcription factor AP-1 and its corresponding cis element were specifically down-regulated. Exposure of anergic T cells to interleukin-2...

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PMID: 1509265
DOI: 10.1126/science.257.5073.1134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transactivation by AP-1 is a molecular target of T cell clonal anergy.PMID 1509265Read ↗

Multifactor cis-dominant negative regulation of IL-2 gene expression in anergized T cells.Semantic proximity Read ↗

T-cell anergy: from phenotype to genotype and back.Semantic proximity Read ↗

Induction and stability of the anergic phenotype in T cells.Semantic proximity Read ↗

Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists.Semantic proximity Read ↗

Early Growth Response Gene-2, a Zinc-Finger Transcription Factor, Is Required for Full Induction of Clonal Anergy in CD4+ T CellsSemantic proximity Read ↗

The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells.Semantic proximity Read ↗

"Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype.Semantic proximity Read ↗

Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cellsSemantic proximity Read ↗

A unique unresponsive CD4+ T cell phenotype post TCR antagonism.Semantic proximity Read ↗

CD28 mRNA rapidly decays when activated T cells are functionally anergized with specific peptide.Semantic proximity Read ↗

Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism.Semantic proximity Read ↗

Persistence of peptide-induced CD4+ T cell anergy in vitro.Semantic proximity Read ↗

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