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Article

Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells

5 Dec 2006

Abstract excerpt

In T cells anergy may be evoked by an unbalanced stimulation of the T-cell receptor in the absence of costimulation. Anergic T cells are unresponsive to new antigen receptor engagement and do not produce interleukin 2. We present evidence that anergizing stimuli induce changes in histone acetylation, which mediates transcriptional repression of interleukin 2 expression. In response to calcium signaling, anergic T...

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PMID: 17148585
DOI: 10.1182/blood-2006-07-037754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cellsPMID 17148585Read ↗

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Early Growth Response Gene-2, a Zinc-Finger Transcription Factor, Is Required for Full Induction of Clonal Anergy in CD4+ T CellsSemantic proximity Read ↗

"Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype.Semantic proximity Read ↗

Ikaros sets thresholds for T cell activation and regulates chromosome propagation.Semantic proximity Read ↗

The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells.Semantic proximity Read ↗

Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists.Semantic proximity Read ↗

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