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Article

"Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype.

The Journal of experimental medicine - 1 Feb 1994

Gajewski T F, Lancki D W, Stack R, Fitch F W

Abstract excerpt

Mature CD4+ helper T lymphocytes have been categorized into two major functional phenotypes, TH1 and TH2, which produce distinct arrays of lymphokines and which are thought to arise from a pluripotential precursor cell termed TH0. Clonal anergy can be induced in TH1 clones by stimulating via the T cell receptor (TCR) complex in the absence of a costimulator molecule; however, anergy has been difficult to...

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Identifiers

PMID: 8294862
DOI: 10.1084/jem.179.2.481
PMCID: PMC2191376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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"Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype.PMID 8294862Read ↗

T-cell anergy: from phenotype to genotype and back.Semantic proximity Read ↗

Early Growth Response Gene-2, a Zinc-Finger Transcription Factor, Is Required for Full Induction of Clonal Anergy in CD4+ T CellsSemantic proximity Read ↗

Induction and stability of the anergic phenotype in T cells.Semantic proximity Read ↗

Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls anergy induction by both agonists and partial agonists.Semantic proximity Read ↗

Transactivation by AP-1 is a molecular target of T cell clonal anergy.Semantic proximity Read ↗

Persistence of peptide-induced CD4+ T cell anergy in vitro.Semantic proximity Read ↗

The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells.Semantic proximity Read ↗

Multifactor cis-dominant negative regulation of IL-2 gene expression in anergized T cells.Semantic proximity Read ↗

Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism.Semantic proximity Read ↗

CD28 mRNA rapidly decays when activated T cells are functionally anergized with specific peptide.Semantic proximity Read ↗

A unique unresponsive CD4+ T cell phenotype post TCR antagonism.Semantic proximity Read ↗

Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cellsSemantic proximity Read ↗

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