Article
"Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype.
The Journal of experimental medicine - 1 Feb 1994
Gajewski T F, Lancki D W, Stack R, Fitch F W
Abstract excerpt
Mature CD4+ helper T lymphocytes have been categorized into two major functional phenotypes, TH1 and TH2, which produce distinct arrays of lymphokines and which are thought to arise from a pluripotential precursor cell termed TH0. Clonal anergy can be induced in TH1 clones by stimulating via the...
Topics
- Animals
- Antibodies, Monoclonal
- B-Lymphocytes
- CD3 Complex
- Calcium
- Cells, Cultured
- Clonal Anergy
- Down-Regulation
- Female
- Humans
- Interleukin-2
- Interleukin-4
- Ionomycin
- Mice
- Mice, Inbred BALB C
- Mice, Inbred CBA
- Mice, Inbred DBA
- Phenotype