Article
Superantigen-reactive T cells that display an anergic phenotype in vitro appear functional in vivo.
International immunology - 1 Jan 1995
Heeg K, Gaus H, Griese D, Bendigs S, Miethke T, Wagner H
Abstract excerpt
Clonal deletion and/or inactivation establishes tolerance to self antigens. Endogenous and exogenous (bacterial) superantigens, like the staphylococcal enterotoxins, induce ligand-specific clonal anergy in vivo and thus are believed to mirror aspects of post-thymic tolerance mechanisms in mature peripheral T cells. Here we analyzed the level of anergy of ligand-responsive V beta 8+ T cells from staphylococcal...
Topics
- Animals
- Enterotoxins
- Gene Expression
- Humans
- Immune Tolerance
- In Vitro Techniques
- Interleukin-2
- Lymphocyte Activation
- Mice
- Mice, Inbred BALB C
- Phenotype
- RNA, Messenger