Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced cell surface expression of HLA-C molecules correlates with restricted peptide binding and stable TAP interaction.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 1998

Neisig A, Melief C J, Neefjes J

Abstract excerpt

HLA-C molecules are poorly expressed at the cell surface compared with HLA-A and HLA-B locus products. The reason for the low surface expression and the underlying mechanism is unclear. We show that the HLA-C4 allele is expressed intracellularly in amounts similar to HLA-A and HLA-B alleles. However, the majority of the HLA-C4 molecules is not transported, but is retained in the endoplasmic reticulum by stable...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to ATP-Binding Cassette Transporters

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to B-Lymphocytes

Share to Binding, Competitive

Share to Cell Membrane

Share to Cells, Cultured

Share to Peptides

Share to Protein Binding

Source

Identifiers

PMID: 9551969

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced cell surface expression of HLA-C molecules correlates with restricted peptide binding and stable TAP interaction.PMID 9551969Read ↗

Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing.Semantic proximity Read ↗

Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP.Semantic proximity Read ↗

A single bottleneck in HLA-C assembly.Semantic proximity Read ↗

TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide.Semantic proximity Read ↗

Natural variants of the immunodominant HLA A11-restricted CTL epitope of the EBV nuclear antigen-4 are nonimmunogenic due to intracellular dissociation from MHC class I:peptide complexes.Semantic proximity Read ↗

HLA-B27-restricted antigen presentation in the absence of tapasin reveals polymorphism in mechanisms of HLA class I peptide loading.Semantic proximity Read ↗

The membrane-bound and soluble forms of HLA-G bind identical sets of endogenous peptides but differ with respect to TAP associationSemantic proximity Read ↗

Distinct mechanisms survey the structural integrity of HLA-B*27:05 intracellularly and at the surface.Semantic proximity Read ↗

Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells.Semantic proximity Read ↗

The Truncated Cytoplasmic Tail of HLA-G Serves a Quality-Control Function in Post-ER CompartmentsSemantic proximity Read ↗

HLA-C revisited. Ten years of change.Semantic proximity Read ↗

Lymphoblastoid cells express HLA‐B27 homodimers both intracellularly and at the cell surface following endosomal recyclingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.