Article
Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway.
Current biology : CB - 1 May 1996
Brown J L, Stowers L, Baer M, Trejo J, Coughlin S, Chant J
Abstract excerpt
BACKGROUND: The Rho-related GTP-binding proteins Cdc42 and Rac1 have been shown to regulate signaling pathways involved in cytoskeletal reorganization and stress-responsive JNK (Jun N-terminal kinase) activation. However, to date, the GTPase targets that mediate these effects have not been identified. PAK defines a growing family of mammalian kinases that are related to yeast Ste20 and are activated in vitro...
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