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Article

PAK thread from amoeba to mammals

6 Apr 2009

Abstract excerpt

The p21-activated kinases (PAKs) are signaling nodes that play a crucial role in cellular processes including cell motility, differentiation, survival, gene transcription, and hormone signaling. PAKs are highly conserved family of serine-threonine kinases that act as effector for small GTPases Rac and Cdc42. Most of our knowledge about PAK functions has been derived from genetic approaches in lower organisms and...

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PMID: 19350548
DOI: 10.1002/jcb.22159

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