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Article

Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade.

Genes & development - 15 Sept 1996

Hu M C, Qiu W R, Wang X, Meyer C F, Tan T H

Abstract excerpt

The c-Jun amino-terminal kinases (JNKs)/stress-activated protein kinases (SAPKs) play a crucial role in stress responses in mammalian cells. The mechanism underlying this pathway in the hematopoietic system is unclear, but it is a key in understanding the molecular basis of blood cell differentiation. We have cloned a novel protein kinase, termed hematopoietic progenitor kinase 1 (HPK1), that is expressed...

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Identifiers

PMID: 8824585
DOI: 10.1101/gad.10.18.2251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade.PMID 8824585Read ↗

Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase.Semantic proximity Read ↗

Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase.Semantic proximity Read ↗

A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1.Semantic proximity Read ↗

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway.Semantic proximity Read ↗

Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1.Semantic proximity Read ↗

Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes.Semantic proximity Read ↗

Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1.Semantic proximity Read ↗

The platelet-derived growth factor controls c-myc expression through a JNK- and AP-1-dependent signaling pathway.Semantic proximity Read ↗

From JNK to Pay Dirt: Jun Kinases, their Biochemistry, Physiology and Clinical ImportanceSemantic proximity Read ↗

Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation.Semantic proximity Read ↗

Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.Semantic proximity Read ↗

HPK1 competes with ADAP for SLP‐76 binding and <i>via</i> Rap1 negatively affects T‐cell adhesionSemantic proximity Read ↗

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