Article
Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade.
Genes & development - 15 Sept 1996
Hu M C, Qiu W R, Wang X, Meyer C F, Tan T H
Abstract excerpt
The c-Jun amino-terminal kinases (JNKs)/stress-activated protein kinases (SAPKs) play a crucial role in stress responses in mammalian cells. The mechanism underlying this pathway in the hematopoietic system is unclear, but it is a key in understanding the molecular basis of blood cell differentia...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Cycle Proteins
- Cloning, Molecular
- Enzyme Activation
- GTP-Binding Proteins
- Hematopoietic Stem Cells
- Humans
- JNK Mitogen-Activated Protein Kinases
- MAP Kinase Kinase 4
- MAP Kinase Kinase Kinase 1
- Mitogen-Activated Protein Kinase Kinases
- Mitogen-Activated Protein Kinases
- Molecular Sequence Data
- Mutation
- Phosphorylation