Article
Cell surface receptor function of amyloid precursor protein that activates Ser/Thr kinases.
Gerontology - 1 Jan 1996
Murayama Y, Takeda S, Yonezawa K, Giambarella U, Nishimoto I, Ogata E
Abstract excerpt
Amyloid precursor protein (APP) has been shown to serve as a G(o)-coupled receptor in cell-free systems [Okamoto et al: J Biol Chem 1995;270:4205-4208]. However, it has not been known whether APP exerts intracellular signaling functions in living cells. In this study, we show that stimulation of...
Topics
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Antibodies
- COS Cells
- Calcium-Calmodulin-Dependent Protein Kinases
- Clone Cells
- Enzyme Activation
- Female
- Glioma
- Injections
- Mitogen-Activated Protein Kinase 1
- Mutation
- Oocytes
- Protein Serine-Threonine Kinases
- RNA, Complementary
- Receptors, Cell Surface
- Tumor Cells, Cultured