Article
Cell surface receptor function of amyloid precursor protein that activates Ser/Thr kinases.
Gerontology - 1 Jan 1996
Murayama Y, Takeda S, Yonezawa K, Giambarella U, Nishimoto I, Ogata E
Abstract excerpt
Amyloid precursor protein (APP) has been shown to serve as a G(o)-coupled receptor in cell-free systems [Okamoto et al: J Biol Chem 1995;270:4205-4208]. However, it has not been known whether APP exerts intracellular signaling functions in living cells. In this study, we show that stimulation of APP by anti-APP antibody as well as by a mutation found in familial Alzheimer's disease results in activation of a...
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