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Article

A new paradigm for neurotoxicity by FAD mutants of betaAPP: a signaling abnormality.

Neurobiology of aging - 1 Jan 2000

Nishimoto I

Abstract excerpt

We have demonstrated that normal betaAPP695 behave as a signaling receptor and indicated that point mutations at V642 create autoactive betaAPP in signal transduction. Cellular expression of those familial Alzheimer's disease-associated mutants causes neuronal cells to undergo apoptotic death; an...

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Source

Identifiers

PMID: 9562465
DOI: 10.1016/s0197-4580(98)00040-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9562465-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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