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Article

Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau.

Acta neuropathologica - 1 Jun 2015

Takahashi Muneaki, Miyata Haruka, Kametani Fuyuki, Nonaka Takashi, Akiyama Haruhiko, Hisanaga Shin-ichi, Hasegawa Masato

Abstract excerpt

Alzheimer's disease (AD) is characterized by extracellular amyloid β (Aβ) deposition and intracellular tau aggregation. Many studies have indicated some association between these processes, but it remains unknown how the two pathologies are linked. In this study, we investigated whether expressio...

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Share to Amyloid beta-Peptides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25869641
DOI: 10.1007/s00401-015-1415-2
PMCID: PMC4436700

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25869641-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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