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Article

Abnormal cleavage of APP impairs its functions in cell adhesion and migration.

Neuroscience letters - 6 Feb 2009

Sheng Baiyang, Song Bo, Zheng Zhenhuan, Zhou Fangfang, Lu Guangyuan, Zhao Nanming, Zhang Xiufang, Gong Yandao

Abstract excerpt

Amyloid precursor protein (APP) is expressed ubiquitously but its wrong cleavage only occurs in central nervous system. In this research, overexpression of wild type human APP695 was found to stimulate the adhesion and migration of N2a cells. In the cells co-transfected by familial Alzheimer's disease (FAD)-linked Swedish mutant of APP695 gene plus big up tri, openE9 deleted presenilin1 gene (N2a/Swe. big up tri,...

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Source

Identifiers

PMID: 19056463
DOI: 10.1016/j.neulet.2008.11.046

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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