Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of amyloid precursor protein expression and secretion via activation of ERK1/2 by hepatocyte growth factor in HEK293 cells transfected with APP751.

Experimental cell research - 15 Jul 2003

Liu Feng, Su Yuan, Li Baolin, Ni Binhui

Abstract excerpt

The increased intracellular levels and aberrant processing of the amyloid precursor protein (APP) are associated with beta-amyloid peptide (A beta) production, cerebrovascular amyloid deposition, and amyloid plaque formation. Here we report that APP level, soluble APP (sAPP) secretion, and A beta...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Protein Precursor
Share to Butadienes
Share to Flavonoids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocyte Growth Factor

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Mitogen-Activated Protein Kinases

Share to Nitriles

Source

Identifiers

PMID: 12837293
DOI: 10.1016/s0014-4827(03)00152-6

Genes

APP
HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12837293-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Regulation of amyloid precursor protein expression and secretion via activation of ERK1/2 by hepatocyte growth factor in HEK293 cells transfected with APP751.PMID 12837293Read ↗

Amyloid precursor protein promotes the migration and invasion of breast cancer cells by regulating the MAPK signaling pathwaySemantic proximity Read ↗

Increased beta-amyloid release and levels of amyloid precursor protein (APP) in fibroblast cell lines from family members with the Swedish Alzheimer's disease APP670/671 mutation.Semantic proximity Read ↗

Amyloid-β precursor protein promotes cell proliferation and motility of advanced breast cancerSemantic proximity Read ↗

Cell surface receptor function of amyloid precursor protein that activates Ser/Thr kinases.Semantic proximity Read ↗

Unexpected beta-amyloid production by middle doses of resveratrol through stabilization of APP protein and AMPK-mediated inhibition of trypsin-like proteasome activity in a cell model of Alzheimer's disease.Semantic proximity Read ↗

Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-alpha in intracerebroventricular beta-amyloid-(1-40) infused rats and human embryonic kidney 293 Swedish mutant cells.Semantic proximity Read ↗

Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding.Semantic proximity Read ↗

Overexpression of APP stimulates basal and constitutive exocytosis in PC12 cells.Semantic proximity Read ↗

Endogenous beta-amyloid peptide synthesis modulates cAMP response element-regulated gene expression in PC12 cells.Semantic proximity Read ↗

Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.