Article
Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein.
Molecular and cellular biology - 1 Nov 2005
Hashimoto Yuichi, Chiba Tomohiro, Yamada Marina, Nawa Mikiro, Kanekura Kohsuke, Suzuki Hiroaki, Terashita Kenzo, Aiso Sadakazu, Nishimoto Ikuo, Matsuoka Masaaki
Abstract excerpt
APP, amyloid beta precursor protein, is linked to the onset of Alzheimer's disease (AD). We have here found that transforming growth factor beta2 (TGFbeta2), but not TGFbeta1, binds to APP. The binding affinity of TGFbeta2 to APP is lower than the binding affinity of TGFbeta2 to the TGFbeta receptor. On binding to APP, TGFbeta2 activates an APP-mediated death pathway via heterotrimeric G protein G(o), c-Jun...
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