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Article

Inhibition of neuronal calcium oscillations by cell surface APP phosphorylated on T668.

Neurobiology of aging - 1 Dec 2011

Santos Susana Ferrao, Tasiaux Bernadette, Sindic Christian, Octave Jean-Noël

Abstract excerpt

Adenoviral expression of human APP (hAPP), but not of hAPP deleted from its C-terminal intracellular domain, in rat cortical neurons abolishes spontaneous synchronous calcium oscillations. The intracellular domain of APP695 contains several residues that can be phosphorylated. Contrary to non-neuronal cells, a very high phosphorylation of APP on T668 is observed in neurons, which is mediated by JNK, GSK3 and Cdk5...

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Source

Identifiers

PMID: 20122754
DOI: 10.1016/j.neurobiolaging.2010.01.006

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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